EFFECT OF POLYMORPHISM ON NEW DRUG FORMULATION AND DEVELOPMENT: A SHORT REVIEW

Abstract

The polymorphism of pharmaceutically active drugs has a major impact in the formulation, development and introducing it into the market. Manufacturing a stable and potent active pharmaceutical ingredient, is an important role of pharmacists, and it could be made by research and evaluation of polymorphs that might be probably studied on the drug. The objective of polymorphism and its application is to create a better product, and avoid manufacturing issues by studying the polymorphs of various drugs and the differences between their polymorphic forms. Polymorphism principally centers on solid pharmaceuticals and affects their characteristics such as melting point, boiling point, free energy, dissolution property, shelf life, viscosity, adsorption, bio availability, solubility etc., which may cause manufacturing difficulties of the drug. So, the data of polymorphism of drugs through various lab studies is essential to avoid them. In the case of production of a new drug, polymorphs of the drug have great influence from the production to the preclinical studies of the drug. Then the new drug enters the market after being subjected to tests which include considering the possible polymorphs of the drug and evaluating their stabilities for a longer shelf life and desirable therapeutic action. Polymorphism has been studied over more than 50 years and it still has a huge scope in the present and future of the pharmaceutical field.