Global Journal of Pharma and Paramedical Research(PPMR) [ISSN: 2583-4479]

A SHORT REVIEW ON TARGETED DRUG DELIVERY SYSTEM: FOCUS ON ADVANCED THERAPUETICS AND DIAGNOSIS

2023-01-18T17:42:32+00:00

Delivering a drug to supply its therapeutic effect in the targeted site of
diseased human tissue in a human body with low toxicity is known as
targeted drug delivery system. It has numerous advantages like
reducing the frequency of drug dosage of patients, also performing a
uniform therapeutic effect of a drug with reduced side effects and
toxicity. This system is also known as a "Smart drug delivery" Its
ultimate goal is to achieve pharmaceutical and therapeutic effects in
the system. Liposomes act as an important tool for targeted drug
delivery systems which is a long-circulating macromolecular carrier
with enhanced permeability and retention. This system mainly
concentrates on delivering the nanoparticles of a drug only in the
infected tissue without the interaction of healthy tissue. A Targeted
drug delivery system is widely used in cancer therapy treatments such
as chemotherapy to get the required therapeutic effect on the tumor.

BRIEF OVERVIEW OF THE LAWS AND RULES GOVERNING THE USE OF ANIMALS IN RESEARCH

2023-01-18T17:53:04+00:00

More emphasis has been laid on the welfare of animals and the
morality of this approach as its use in research projects has increased.
Dissemination of knowledge regarding current ethical issues and
alternatives in animal experimentation serves two crucial purposes:
first, it makes researchers more aware of potential ways to use animals
in experiments, and second, it makes sure that potential users are
aware of the available alternatives. It is not a privilege to be able to
utilise animals in research labs. Certain members of the scientific
community have been granted this privilege by society, and it comes
with the need to abide by the relevant laws, regulations, policies, and
standards as well as work to improve them. For instance, laws passed
in many nations throughout the 1980s mandate that applications using
laboratory animals should be minimised, improved, and replaced
whenever possible in accordance with the 3Rs. As a result, experts
from around the world worked to put the 3Rs into practise to safeguard
the wellbeing of laboratory animals used in scientific research. This
review article covers a collection of articles that examine how animal
laws, regulations, and standards operate in various nations.

Recent Advancements in Transdermal Drug Delivery for Herbal Therapy

2023-01-18T18:01:46+00:00

Although transdermal drug shipping has appreciably
improved medical practice, it has no longer yet reached its full
capability as an alternative to oral transport and hypodermic
injections. For the shipping of tiny, lipophilic, low-dose drugs,
scientific use of first-generation transdermal delivery devices has
gradually increased. Clinical items have also been produced
employing second-era transport structures that use chemical
enhancers, non-cavitation ultrasound, and iontophoresis; the latter's
capacity to alter distribution quotes in real time provides the
capability. Using microneedles, thermal ablation, microdermabrasion,
electroporation, and cavitation al ultrasound, third-generation delivery
structures listen to their outcomes on the stratum corneum, the pores,
and the skin's outermost barrier layer. Vaccines and macromolecules
together with insulin, parathyroid hormone, and influenza vaccine are
currently being brought through medical trials using microneedles and
thermal ablation. Transdermal shipping is poised to have a widespread
impact on medication through the usage of those cutting-edge second
and third- generation augmentation techniques.

Nanosponges: A Novel Class of Versatile Drug Delivery System – Review

2023-01-20T18:07:54+00:00

Nanotechnology advancements have resulted in the creation of tailored medicine delivery systems. However, properly targeting a molecule to a specific region with a drug delivery system necessitates using a specialized drug delivery system. The development of nanosponge has become a crucial step in solving some challenges such as drug toxicity, low bioavailability, and predictable drug release. Many drug delivery methods, such as nanoparticles, nanoemulsions, nanosuspensions, and nanosponges, have been developed via nanomedicine technology. Nanosponges are little sponges like the size of a virus that may be loaded with a vast range of medications. Nanosponges serve an essential function in regulated medication delivery. These mini sponges may flow throughout the human body until they reach the same target region. They adhere to the surface and begin to release the medicine in a regulated and predictable way. The outside surface is often porous, which allows for regulated medication release. The important feature of these sponges is their aqueous solubility, which makes them appropriate for medications with low solubility. Their molecular architecture is often composed of several polymer chains that can generate unique microdomains suited for co-encapsulating two medicines with different chemical structures. When used to release insoluble medications, nanosponges also shield the active components from physicochemical deterioration. Nanosponges can be made into a number of dosage forms, including parenteral, aerosol, tablets, topical, and capsules, thanks to their small size and spherical structure. This study focuses on the techniques of synthesis and applications of nanosponges in the realm of medication delivery.

A Review on Nano-Approaches Against Periodontitis Treatment

2023-01-20T19:06:32+00:00

Periodontitis is a provocative condition of the secretions that destroys the alveolar bone, the formation of periodontal pockets, and the degeneration of periodontal ligaments. WHO estimates that between 10 and 15 percent of people worldwide have severe periodontitis. The development of a wide variety of microflora, particularly anaerobes, in the compartments, the release of toxins and enzymes, and the stimulation of the body's immune system are the causes of the disease. Periodontitis was effectively treated using a variety of local or systemic methods. Currently, site-specific delivery, low dose requirements, bypassing first-pass metabolism, a reduction in gastrointestinal side effects, and other factors make the controlled local drug delivery approach preferable to the general approach because it primarily focuses on improving therapeutic outcomes. It offers a safe and efficient way of therapy overall, which improves patient compliance. Various surgical and mechanical procedures completely failed to eradicate the areas' germs. Numerous polymer-based delivery methods, including fibers, films, chips, strips, microparticles, nanoparticles, and nanofibers manufactured from various natural and synthetic materials, have been investigated to successfully transport various medications. These solutions have good mucoadhesion qualities, are Fill the pockets, have high retention at the target site, and are biocompatible and biodegradable. The study gives a general summary of all the different periodontitis targeted delivery systems that are now available and being created.