Nanosponges: A Novel Class of Versatile Drug Delivery System – Review
DOI:
https://doi.org/10.58260/j.ppmr.2202.0110Keywords:
Nanosponges, Nanomedicine, Parenteral, Aerosol, Topical, bioavailabilityAbstract
Nanotechnology advancements have resulted in the creation of tailored medicine delivery systems. However, properly targeting a molecule to a specific region with a drug delivery system necessitates using a specialized drug delivery system. The development of nanosponge has become a crucial step in solving some challenges such as drug toxicity, low bioavailability, and predictable drug release. Many drug delivery methods, such as nanoparticles, nanoemulsions, nanosuspensions, and nanosponges, have been developed via nanomedicine technology. Nanosponges are little sponges like the size of a virus that may be loaded with a vast range of medications. Nanosponges serve an essential function in regulated medication delivery. These mini sponges may flow throughout the human body until they reach the same target region. They adhere to the surface and begin to release the medicine in a regulated and predictable way. The outside surface is often porous, which allows for regulated medication release. The important feature of these sponges is their aqueous solubility, which makes them appropriate for medications with low solubility. Their molecular architecture is often composed of several polymer chains that can generate unique microdomains suited for co-encapsulating two medicines with different chemical structures. When used to release insoluble medications, nanosponges also shield the active components from physicochemical deterioration. Nanosponges can be made into a number of dosage forms, including parenteral, aerosol, tablets, topical, and capsules, thanks to their small size and spherical structure. This study focuses on the techniques of synthesis and applications of nanosponges in the realm of medication delivery.
References
Yadav GV, Panchory HP. Nanosponges–a boon to the targeted drug delivery system. J Drug Delivery Ther 2013;3:151-5.
Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR. Recent advances in nanosponges as drug delivery system. Int J Pharm SciNanotechnol 2013;6:1934-44.
Aritomi H, Yamasaki Y, Yamada K,Honda, Khoshi M, Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. J Pharma Sci Tech 1996; 56(1): 49-56 https://doi.org/10.1208/s12249-011-9663-5
Yurtdas G, Demirel M, Genc L. Inclusion complexes of fluconazole with beta-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation. J Incl Phenom MacrocyclChem 2011; 70: 429–435; https://doi.org/10.1007/s10847-010-9908-z
Liang L, De-Pei L, Chih-Chuan L. Optimizing the delivery systems of chimeric RNA DNA Oligonucleotides beyond general oligonucleotide transfer. Eur J Biochem 2002; 269: 5753–5758 https://doi.org/10.1046/j.1432-1033.2002.032.x
Singh D, Soni GC, Prajapati SK. Recent advances in nanosponges as drug delivery system: a review. Eur J Pharm Med Res 2016;3:364-71.
Zuruzi S, MacDonald NC, Moskovits M, Kolmakov A. Metal oxide nanosponges as chemical sensors: Highly sensitive detection of hydrogen using nanospongetitania; AngewandteChemie 2007; 46 (23): 4298-4301. https://doi.org/10.1002/anie.200700006
Swaminathan S, Vavia PR, Trotta F. Formulation of beta cyclodextrins based nanospongesofitraconazole. J Incl Phenom Macro Chem 2007; 57:89-94. https://doi.org/10.1007/s10847-006-9216-9 .
Wong VN, Fernando G, Wagner AR, Zhang J, Kinsel GR, Zauscher S, Dyer DJ. Separation of peptides with polyionicnanosponges for MALDIM Sanalysis. Langmuir 2009; 25(3):1459-65.
Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges. EP 1 786 841 B1; 2007.
Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia P. Nanosponge formulations as oxygen delivery systems. Int J Pharm 2010; 402(1-2): 254-257.
Ansari KA, Torne S, Vavia PR, Trotta F, Cavalli R. Cyclodextrin based nanosponges for delivery of resveratrol: In vitro characterization, stability, cytotoxicity and permeation study. AAPS Pharm Sci Tech 2011; 12: (1), 279-86.https://doi.org/10.1208/s12249-011-9584-3
Yadav G, Panchory H. Nanosponges: a boon to the targeted drug delivery system. J Drug DelivTherap 2013; 3(4): 151-155.http://dx.doi.org/10.22270/jddt.v3i4.564.
Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrinnanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135.
Lala R, Thorat A, Gargote C. Current trends in βcyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526.
Indira B, Bolisetti SS. Nanosponges: a new era in drug delivery. J Pharm Res 2012;5:5293-6.
Sharma R, Pathak K. Nanosponges: Emerging drug delivery system. Pharma Stud; 2010. p. 33-5.
Renuka S, Roderick BW, Kamla P. Evaluation of the kinetics and mechanism of drug release from Econazole Nitrate nanosponge loaded carbapol hydrogel. Ind J Parm Edu 2011; 45(1): 25-31.
Amber V, Shailendra S, Swarnalatha S. Cyclodextrin based novel drug delivery systems. J Incl Phenom MacrocyclChem, 2008; 62:23-42.
Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSciTech, 2005; 6(2):E329-E357.
Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes –A Review. J Pharm Sci Tech, 2010; 2(3):171-183.
Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm, 2010; 74: 193-201.
Patil B S, Mohite SK. Formulation design and development of artesunatenanosponge. Eur J Pharm Med Res 2016; 3(5): 206-211.
Renuka S, Roderick BW, Kamala P. Evaluation of the kinetics and mechanism of drug release from econozole nitrate nanosponge loaded carbapol hydrogel. Ind J Parm Edu Res 2011; 45:25-31. https://doi.org/10.1081/DDC-120016687
Amber V, Shailendra S, Swarnalatha S. Cyclodextrin based novel drug delivery systems. J Incl Phenom MacrocyclChem 2008; 62:23-42 https://doi.org/10.1016/j.carbpol.2007.10.019
Farooq SA, Saini V. Application of novel drug delivery system in the pharmacotherapy of hyperlipidemia. J Chem Pharm Sci 2013;6:138-46.
Trotta F, Dianzani C, Caldera F, Mognetti B, Cavalli R. The application of nanosponges to cancer drug delivery. Expert Opinion Drug Delivery 2014;11:931-41.
Martin A, Swarbrick J, Cammarrata A. In: physical pharmacy–physical chemical principles in pharmaceutical sciences 1991; 3: 527
Che-Ming J Hu, Ronnie H Fang, Jonathan Copp, Brian T Luk, Liangfang Zhang. A biomimetic nanosponge that absorbs pore-forming toxins. Nat Nanotechnol 2013;8:336–40.
Emanuele AD, Dinarvand R. Preparation, characterization and drug release from thermo responsive microspheres. Int J Pharm 1995; 237-242.
Naga SJ, Nissankararao S, Bhimavarapu R, Sravanthi S, Vinusha K. Nanosponges: a versatile drug delivery system. Int J Pharm Life Sci 2013;4:2920-5.
Güngör S, Erdal MS, Aksu B. New formulation strategies in topical antifungal therapy. J CosmetDermatolSciAppl 2013;3:56.
Trotta F. Cyclodextrinnanosponges and their applications. Cyclodextrins in pharmaceutics, cosmetics, and biomedicine. Current and Future Industrial Applications 2011. p. 323-42.
Kaur G, Aggarwal G, Harikumar SL. Nanosponge: New colloidal drug delivery system for topical delivery. Indo Global J Pharm Sci 2015;5:53-7.
RenuKadian. Nanoparticles: a promising drug delivery approach. Asian J Pharm Clin Res 2018;11:30-5.
Leslie Z. Benet., BCS and BDDCS. Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability. Department of biopharmaceutical sciences, University of California, San Francisco, USA, 2007.
Rosalba M, Roberta C, Roberto F, Chiara D, Piergiorgio P, Leigh E, Li S, Roberto P. Antitumor activity of nanosponge-encapsulated Camptotechin in human prostate tumors. Cancer Res,2011; 71:4431
Torne SJ, Ansari KA, Vavia PR, Trotta F, Cavalli R. Enhanced oral Paclitaxel bioavailability after administration of Paclitaxel loaded nanosponges. Drug Delivery, 2010; 17(6):419–425.
Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Curr Drug Deliv, 2011; 8(2):194- 202.
Shankar S, Vavia PR, Francesco T, Satyen T. Formulation of Betacyclodextrin based nanosponges of Itraconazole. J Incl Phenom MacrocyclChem, 2007; 57: 89–94.
Isabelle A, Christine V, Helene C, Elias F, Patrick C. Spongelike Alginate Nanoparticles as a new potential system for the delivery of Antisense Oligonucleotides. Antisense and Nucleic Acid Drug Development, 1999; 9(3): 301-312.
Published
How to Cite
License
Copyright (c) 2022 Global Journal of Pharma and Paramedical Research(PPMR) [ISSN: 2583-4479]
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.